leaky cell membranes

I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms.  Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

Thanks!  Amy

> I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms.  Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

I doubt that his theory about leaky cell membranes applies to EVERYONE on this list.  I think there are various causes of ES, and you need to figure out which one applies to you.  For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning.  While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes.  And many people here probably have a combination of several things going on.

Marc

My take on this? Everyone suffers! You can divide this into two groups. Those like us who have learned to recognize the real culprit in a wide list of varied symptoms. And those who have the same or similiar symptoms but DON"T recognize the source. "Got a head-ache, pop an advil/motrin". High blood pressure? Diabetes? Chronic Fatigue? Allergies, Runny nose, sinus problems,  Heart Problems? Take a pill.
And far too often, the pills MASK the effects just "enough" for the majority of people to put the BLAME- on something else. Next time all of you are in a gathering of people, count how many you find that DON"T have ANY chronic health problems. That includes: asmtha, allergies, migraines,thinning hair or hair loss, missing eye brows (looks like they over plucked) circles under the eyes, sunken eyes, over-weight, under-weight, acne, red face, wears eye glasses, or contacts, food allergies, sour stomach, indigestion, heavy periods, depression, FLAT expression (TOTAL APATHY- like no feelings), arthritus, lupus, anxiety, compulsive, always tired, ....the list goes on and on.
I bet if you had 20 people, you wouldn't find ONE that didn't HAVE SOME KIND OF HEALTH PROBLEM. We had pesticides, mercury, silver fillings, badly polluted air, plastic crap, teflon pans, and lots of other things 20 years ago. WHAT WE DIDN'T HAVE WAS AN ENVIRONMENT LOADED WITH WIRELESS RADIATION to the point we do now. The common denomimator in all of this is WIRELESS radiation.
To me? This is the straw that broke the camels back.
Blessings,
Lizzie
 


To: [hidden email]
From: [hidden email]
Date: Tue, 31 May 2011 09:21:34 -0700
Subject: Re: [eSens] leaky cell membranes


 



> I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

I doubt that his theory about leaky cell membranes applies to EVERYONE on this list. I think there are various causes of ES, and you need to figure out which one applies to you. For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning. While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes. And many people here probably have a combination of several things going on.

Marc



     

[Non-text portions of this message have been removed]

Can I have the link for this talk?

Many thanks,

K

--- In [hidden email], "Amy" <amygreen53@...> wrote:
>
> I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms.  Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???
>
> Thanks!  Amy
>

> Can I have the link for this talk?

Here you go:

  http://emfjournal.com/2009/10/11/electrohypersensitivity-emsmechanisms/

Like I said, I think he is oversimplifying ES, as I think there are multiple
possible causes of ES.

Marc

Besides the leaky cell membrane, other biological effects found under research are given at http://www.wireless-precaution.com/main/science.php.  These include DNA breaks, increased free radical activity, calcium efflux affecting the brain and heart, increased production of histamines, blood cell clumping, and more.

This might give you some suggestions such as increasing levels of  antioxidants, getting adequate magnesium to balance calcium, etc.
http://www.wireless-precaution.com/main/nutrition.php

--- In [hidden email], "Marc Martin" <marc@...> wrote:
>
> > I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms.  Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???
>
> I doubt that his theory about leaky cell membranes applies to EVERYONE on this list.  I think there are various causes of ES, and you need to figure out which one applies to you.  For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning.  While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes.  And many people here probably have a combination of several things going on.
>
> Marc
>

Hi, Emraware,
 
You write:
Besides the leaky cell membrane, other biological effects found under research are given at http://www.wireless-precaution.com/main/science.php. These include DNA breaks, increased free radical activity, calcium efflux affecting the brain and heart, increased production of histamines, blood cell clumping, and more.
 
I reply:
Leaky cell membrane (tight junction permeability), however, is much more than an effect in ES (as well as the dozen or more illnesses people with ES are also likely to have).  It is an affect.  And most of the other symptoms you list are also caused by tj permeability or are secondary to problems directly caused by it.  And tj permeability, itself, is a genetic condition.  Calcium efflux is directly caused by tj permeability in both the brain and the heart. The other problems you mention are secondary to other problems caused by tj permeability.  I am not able to be online very long any more due to "real life", however, in a short amount of time last night, I was able to find these excerpts just by googling the words "tight junction permeability":

"In a relatively short time, our knowledge of the tight junction has evolved from a relatively simple view of it being a permeability barrier in the paracellular space and a fence in the plane of the plasma membrane to one of it acting as a multicomponent, multifunctional complex that is involved in regulating numerous and diverse cell functions. A group of integral membrane proteins—occludin, claudins, and junction adhesion molecules—interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity."  (found at:)

http://ajpcell.physiology.org/content/286/6/C1213.full

"Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.

In multicellular organisms, epithelia consist of specialized cells that form selective barriers controlling the passage of water, ions, and other small molecules between different body compartments and the external environment. This requires cells to be polarized, that is, to form distinct membrane domains: an apical side, facing the lumen of a body cavity or the outside environment, and a basal side, adjacent to the underlying tissue. For instance, the epithelial cells lining the intestinal lumen are at the interface between the internal and external environments, regulating the absorption of nutrients and water, as well as ion homeostasis. In addition, these cells provide a protective barrier against commensal and pathogenic microorganisms." (found at:)
 
http://physiologyonline.physiology.org/content/25/1/16.full

I have been following this area of medical research since 2000, when Dr. Alessio Fasano and his team of researchers discovered zonulin and zot are increased in those with celiac disease [which I have], and that these (zonuline and zot)breach the gut and bbb tight junction barriers [it is now know they breach many organs].  By 2004, I learned particular emfs also breach the tight junctions.  By 2006, I learned tj permeability was genetic, leading to increased permeability in about 22 to 24% of the population.  At that time, I had to wonder whether those of us with ES (and other diseases such as FM, CFS, MCS, MS, dysautonomia (ANSD), besides celiac disease, are all among those with this tj permeability genetic profile and I mentioned this at this forum around that time or possibly a bit later. For one thing--this would allow for why the cell phone industry was able to find NO side effects caused by cell phone use.  [They cherry pick test subjects who are
 normal (no cfs, no fms, no mcs, no....) instead of people with these diseases!  They clearly state that they have done this on their studies.] Since that time, some researchers are making findings that are consistent with my thoughts that all these "new" diseases are infact linked.  They are all thought to be "ion-channelopathy" diseases now.  Celiac disease was known to be an ion-channelopathy since 2000.

Since that time, (finding other diseases ion-channel linked) doctors such as Goldsworthy have jumped on the bandwagon.  There is continuing research every year that encourages me that this is not a dead-end.  Marc mentions metal hoarding--esp mercury hoarding as a cause of ES.  He is right, it is a cause!  Mercury hoarding is also caused/ made harder to detox by tj permeability! There are research studies out there which show this, however, I sent dozens of these studies last year, and only a few people here were interested.  And I didn't send the studies as I found them before that--with the subjects of what they showed, because before that *nobody* was interested.  It was like Diane's latest, greatest adventure and nobody thought I was correct.  

Unfortunately, since 2009, I no longer have the time to sift thru these studies and share them like I once could have.  I am taking care of my elderly parents, an alzheimers father, and 3 houses.  My time is now tied up in real life.  Lucky I got enough info from the studies myself to at least help me! I have overcome cfs, fms, osteoporosis, (and more) and can well control my ANSD, diabetes, liver disease, chronic bronchial asthma, ES, and CD, so far.  MCS has been the only one which has stayed very resistent.  That and hand tremors still plague me. I assume that hand tremors are toxin related or from lack of a particular enzyme needed, which is GABA related.  (GABA is something I cannot tolerate well, as it leaks into the bbb too readily, from tj permeability.)  

The answers are out there to find if you search for them.  But it takes work and time.  We are all different, that is true; but we are also very much the same.  The sources are there.  Ask and you shall find.  Do I know it all?  Of course not; not even close to a millionth of 1 percent.  But I know what I need to know as I continue to search and ask. I don't close my mind to any doors.  If you do that, you will never find.

My quarter's worth,
Diane





--- On Tue, 5/31/11, emraware <[hidden email]> wrote:


From: emraware <[hidden email]>
Subject: [eSens] Various causes of ES symptoms
To: [hidden email]
Date: Tuesday, May 31, 2011, 8:48 PM


 




This might give you some suggestions such as increasing levels of antioxidants, getting adequate magnesium to balance calcium, etc.
http://www.wireless-precaution.com/main/nutrition.php

--- In [hidden email], "Marc Martin" <marc@...> wrote:
>
> > I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???
>
> I doubt that his theory about leaky cell membranes applies to EVERYONE on this list. I think there are various causes of
 ES, and you need to figure out which one applies to you. For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning. While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes. And many people here probably have a combination of several things going on.
>
> Marc
>

Hi, Amy,
 
Due to time constraints, I haven't time to explain this indepth, however, you will probably get something out of googling "tight junctions" at wikipedia:
 
http://en.wikipedia.org/wiki/Tight_junction
 
When I first read about this in 2000, it was explained that tight junctions are similar to mortar between bricks (the bricks being the body's cells).  [Particularly the mortar at the corners of the bricks.]  They were called, "gate keepers to the body" because they keep out foreign substances.  They were thought to never open, but in ion- channelopathy diseases, it is now known they do.  When they do, all manner of substances which should not be able to enter the blood stream, organs, or blood-brain barrier are left in.  It was once thought this is totally genetic--genes control the permeability of the tight junctions.  I assume this is still true, but since I haven't been actively studying this for awhile, there is a possibility this is not completely true.  What I mean is, perhaps everybody's tjs may open in some circumstances for a short while.  It is now known the tjs react to many different stimuli.  It is also now known that tjs are not
 just gate-keepers, they perform many functions in the body.
 
Glutens, in people with celiac genes, and emfs (possibly due also to other genes, or not) are 2 things which open tjs and destroy their ability to close in time, if not curtailed.  Once tjs can no longer close, you develop ion-channelopathy disease. 
 
This is the short and easy version.  It is much more complicated than this, tho.
 
Hope this helped,
Diane

--- On Tue, 5/31/11, Amy <[hidden email]> wrote:


From: Amy <[hidden email]>
Subject: [eSens] leaky cell membranes
To: [hidden email]
Date: Tuesday, May 31, 2011, 12:12 PM


 



I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

Thanks! Amy








[Non-text portions of this message have been removed]

Evie, do you know if there are any treatments (including "alternative medicine") that have helped alleviate symptoms of high tj permeability?

-E. Drew

--- On Wed, 6/1/11, Evie <[hidden email]> wrote:

From: Evie <[hidden email]>
Subject: Re: [eSens] Various causes of ES symptoms
To: [hidden email]
Date: Wednesday, June 1, 2011, 2:28 PM







 



 


   
     
     
      Hi, Emraware,

 

You write:

Besides the leaky cell membrane, other biological effects found under research are given at http://www.wireless-precaution.com/main/science.php. These include DNA breaks, increased free radical activity, calcium efflux affecting the brain and heart, increased production of histamines, blood cell clumping, and more.

 

I reply:

Leaky cell membrane (tight junction permeability), however, is much more than an effect in ES (as well as the dozen or more illnesses people with ES are also likely to have).  It is an affect.  And most of the other symptoms you list are also caused by tj permeability or are secondary to problems directly caused by it.  And tj permeability, itself, is a genetic condition.  Calcium efflux is directly caused by tj permeability in both the brain and the heart. The other problems you mention are secondary to other problems caused by tj permeability.  I am not able to be online very long any more due to "real life", however, in a short amount of time last night, I was able to find these excerpts just by googling the words "tight junction permeability":



"In a relatively short time, our knowledge of the tight junction has evolved from a relatively simple view of it being a permeability barrier in the paracellular space and a fence in the plane of the plasma membrane to one of it acting as a multicomponent, multifunctional complex that is involved in regulating numerous and diverse cell functions. A group of integral membrane proteins—occludin, claudins, and junction adhesion molecules—interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity."  (found at:)



http://ajpcell.physiology.org/content/286/6/C1213.full



"Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.



In multicellular organisms, epithelia consist of specialized cells that form selective barriers controlling the passage of water, ions, and other small molecules between different body compartments and the external environment. This requires cells to be polarized, that is, to form distinct membrane domains: an apical side, facing the lumen of a body cavity or the outside environment, and a basal side, adjacent to the underlying tissue. For instance, the epithelial cells lining the intestinal lumen are at the interface between the internal and external environments, regulating the absorption of nutrients and water, as well as ion homeostasis. In addition, these cells provide a protective barrier against commensal and pathogenic microorganisms." (found at:)

 

http://physiologyonline.physiology.org/content/25/1/16.full



I have been following this area of medical research since 2000, when Dr. Alessio Fasano and his team of researchers discovered zonulin and zot are increased in those with celiac disease [which I have], and that these (zonuline and zot)breach the gut and bbb tight junction barriers [it is now know they breach many organs].  By 2004, I learned particular emfs also breach the tight junctions.  By 2006, I learned tj permeability was genetic, leading to increased permeability in about 22 to 24% of the population.  At that time, I had to wonder whether those of us with ES (and other diseases such as FM, CFS, MCS, MS, dysautonomia (ANSD), besides celiac disease, are all among those with this tj permeability genetic profile and I mentioned this at this forum around that time or possibly a bit later. For one thing--this would allow for why the cell phone industry was able to find NO side effects caused by cell phone use.  [They cherry pick test subjects who are

 normal (no cfs, no fms, no mcs, no....) instead of people with these diseases!  They clearly state that they have done this on their studies.] Since that time, some researchers are making findings that are consistent with my thoughts that all these "new" diseases are infact linked.  They are all thought to be "ion-channelopathy" diseases now.  Celiac disease was known to be an ion-channelopathy since 2000.



Since that time, (finding other diseases ion-channel linked) doctors such as Goldsworthy have jumped on the bandwagon.  There is continuing research every year that encourages me that this is not a dead-end.  Marc mentions metal hoarding--esp mercury hoarding as a cause of ES.  He is right, it is a cause!  Mercury hoarding is also caused/ made harder to detox by tj permeability! There are research studies out there which show this, however, I sent dozens of these studies last year, and only a few people here were interested.  And I didn't send the studies as I found them before that--with the subjects of what they showed, because before that *nobody* was interested.  It was like Diane's latest, greatest adventure and nobody thought I was correct.  



Unfortunately, since 2009, I no longer have the time to sift thru these studies and share them like I once could have.  I am taking care of my elderly parents, an alzheimers father, and 3 houses.  My time is now tied up in real life.  Lucky I got enough info from the studies myself to at least help me! I have overcome cfs, fms, osteoporosis, (and more) and can well control my ANSD, diabetes, liver disease, chronic bronchial asthma, ES, and CD, so far.  MCS has been the only one which has stayed very resistent.  That and hand tremors still plague me. I assume that hand tremors are toxin related or from lack of a particular enzyme needed, which is GABA related.  (GABA is something I cannot tolerate well, as it leaks into the bbb too readily, from tj permeability.)  



The answers are out there to find if you search for them.  But it takes work and time.  We are all different, that is true; but we are also very much the same.  The sources are there.  Ask and you shall find.  Do I know it all?  Of course not; not even close to a millionth of 1 percent.  But I know what I need to know as I continue to search and ask. I don't close my mind to any doors.  If you do that, you will never find.



My quarter's worth,

Diane



--- On Tue, 5/31/11, emraware <[hidden email]> wrote:



From: emraware <[hidden email]>

Subject: [eSens] Various causes of ES symptoms

To: [hidden email]

Date: Tuesday, May 31, 2011, 8:48 PM



 



This might give you some suggestions such as increasing levels of antioxidants, getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php



--- In [hidden email], "Marc Martin" <marc@...> wrote:

>

> > I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this list. I think there are various causes of

 ES, and you need to figure out which one applies to you. For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning. While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes. And many people here probably have a combination of several things going on.

>

> Marc

>





   
     

   
   


 



 





[Non-text portions of this message have been removed]

OOOOPS Amy, 
 
I got your email mixed up with another person who said they didn't understand any of the tight junction info.
 
Stopping cell membranes from leaking is about addressing open tight junctions.  How you stop tight junction permeability is to stop putting yourself in the way of emfs and glutens and other things which open them.  This is difficult, and sometimes, impossible. 
 
There are some other fixes.  I have found some personally, which I do not like to share on forum, since I can never know if the person using my suggestion is actually *doing* what I am telling them exactly.  And making changes, change the outcome considerably, possibly making you worse.  I once mentioned a supplement mix I was using, which contained manganese.  Manganese can be toxic--it is a toxic metal, not unlike mercury, when taken in a high dose.  So unless you actually need it, you should not be taking it.  I cannot be anybody's doctor.  I can only say that if you understand your body, are very cautious, research well everything you are doing, proceed even more cautiously.... you will find supplement info which will help you, or at least help an open-minded doctor or nutritionist to help you.  The supplements which help me will not necessarily help you.  We are different people with different needs. 
 
I have not had time to research Goldsworthy's site to see whether he has a treatment protocol.  I imagine he does.  I think I tried to find this last year and he doesn't publish his treatment protocol.  But at any rate, there should be workable treatments out there, if not now, soon.  Already, for celiac disease, they are searching for actual cures, not treatments.  It is thought there will be a cure for cd in 17 years--why this amount of time, I have no idea.  lol  However, in the meantime, complete avoidance of gluten works.  [However, for me, I notice some emfs seem to open my gut tjs too, so that is why I have worked so hard to avoid emfs and keep them out of my environment.]
 
Sorry I can't specifically tell you to take thus and so.  It is more complicated than that.  But if you read the studies, you will likely finally find info which you will recognise personally relates to you and your situation.  Then, if you track other studies dealing with those specifics, you probably can find some clues for supplements to try.
 
I started with general info on the research studies and found a particular area which I really related to--I knew it was causing a problem (calcium leaking).  I then looked up studies relating to that particular problem.  I found a research study where they used manganese and taurine to close tight junctions in rabbits corneas, of all places, in order to deal with this problem.  I cautiously tried this in very low doses, plus 2 other supplements at a different time of the day.  It works for me if I do not abuse it.  I do not use it when I do not need it.  I need it only before I am going into very bad emfs.  I personally do not react badly to cell and microwave towers anymore.  I own no digital or wireless stuff.  So I need this supplement mix only particular times and places.  I usually have no problems going shopping now, or to public places.  But I don't abuse my health by going to stores or in highly public places everyday. 
 Mainly I use this mix when I have to go to a particular city near here, where the emfs are off the charts due to multiple antenna and towers, the electrical grid is over loaded, wireless and digital signals abound, etc.
 
Bless you, Amy,
Diane
 


--- On Tue, 5/31/11, Amy <[hidden email]> wrote:


From: Amy <[hidden email]>
Subject: [eSens] leaky cell membranes
To: [hidden email]
Date: Tuesday, May 31, 2011, 12:12 PM


 



I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

Thanks! Amy








[Non-text portions of this message have been removed]

Hi Elysia,
 
Read the second post I just wrote Amy.  I just answered this awhile ago.
 
Also consider raising your pH--I wrote alot about that last week.  That is a problem which would likely be universal. Take supplements to feed your liver detox function.  We all have plenty to detox, due to the tight junction permeability.  Also, compare the email about "bluegreen's" girlfriend's treatments with my recent email (I think yesterday) to newbies.  You will see we do a number of things in common.  Unfortunately, unless you are one of my clones, j/k, my supplement therapy would likely not work for you.  I have met a person here who is a clone almost, of me.  She is going to try the supplements I take, but she is yet having to deal with problems I fixed years before starting the tj supplement mix. 
 
This is another thing--you have to do things in a specific order.  If you haven't dealt with your liver, you cannot detox successfully.  You also need to feed your adrenals and lymphatics to detox.  You also need to clean out the pores of your skin in order to detox.  (With epsom salts, sea salts, baking soda, clays, etc--used separately--usually as soaking baths.)  You may need to support your kidneys to detox.  If you do not detox, you are likely not to get alot out of treating pH.  You need to treat gut flora if that is a problem, and gluten, if that is a problem....  Each of these will hold back other attempts at treatment.  Estrogen and serotonin problems need worked out.....  So, make a list of your problem areas (mine was very long), and then try to find a way to prioritize them.  I messed up multiple times.  You will goof too.  This is okay.  This is not a 2 week program, no matter what some others say.  It is a 2+ year
 commitment.  For some it will be much longer.  And i am not talking cure here, I am talking major improvement.  And you will have to be determined to get there. 
 
Good luck Elysia and bless you,
Diane

--- On Wed, 6/1/11, Elysia Drew <[hidden email]> wrote:


From: Elysia Drew <[hidden email]>
Subject: Re: [eSens] Various causes of ES symptoms
To: [hidden email]
Date: Wednesday, June 1, 2011, 3:17 PM


 



Evie, do you know if there are any treatments (including "alternative medicine") that have helped alleviate symptoms of high tj permeability?

-E. Drew

--- On Wed, 6/1/11, Evie <[hidden email]> wrote:

From: Evie <[hidden email]>
Subject: Re: [eSens] Various causes of ES symptoms
To: [hidden email]
Date: Wednesday, June 1, 2011, 2:28 PM

 

Hi, Emraware,

 

You write:

Besides the leaky cell membrane, other biological effects found under research are given at http://www.wireless-precaution.com/main/science.php. These include DNA breaks, increased free radical activity, calcium efflux affecting the brain and heart, increased production of histamines, blood cell clumping, and more.

 

I reply:

Leaky cell membrane (tight junction permeability), however, is much more than an effect in ES (as well as the dozen or more illnesses people with ES are also likely to have).  It is an affect.  And most of the other symptoms you list are also caused by tj permeability or are secondary to problems directly caused by it.  And tj permeability, itself, is a genetic condition.  Calcium efflux is directly caused by tj permeability in both the brain and the heart. The other problems you mention are secondary to other problems caused by tj permeability. I am not able to be online very long any more due to "real life", however, in a short amount of time last night, I was able to find these excerpts just by googling the words "tight junction permeability":

"In a relatively short time, our knowledge of the tight junction has evolved from a relatively simple view of it being a permeability barrier in the paracellular space and a fence in the plane of the plasma membrane to one of it acting as a multicomponent, multifunctional complex that is involved in regulating numerous and diverse cell functions. A group of integral membrane proteins—occludin, claudins, and junction adhesion molecules—interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity." (found at:)

http://ajpcell.physiology.org/content/286/6/C1213.full

"Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.

In multicellular organisms, epithelia consist of specialized cells that form selective barriers controlling the passage of water, ions, and other small molecules between different body compartments and the external environment. This requires cells to be polarized, that is, to form distinct membrane domains: an apical side, facing the lumen of a body cavity or the outside environment, and a basal side, adjacent to the underlying tissue. For instance, the epithelial cells lining the intestinal lumen are at the interface between the internal and external environments, regulating the absorption of nutrients and water, as well as ion homeostasis. In addition, these cells provide a protective barrier against commensal and pathogenic microorganisms." (found at:)

http://physiologyonline.physiology.org/content/25/1/16.full

I have been following this area of medical research since 2000, when Dr. Alessio Fasano and his team of researchers discovered zonulin and zot are increased in those with celiac disease [which I have], and that these (zonuline and zot)breach the gut and bbb tight junction barriers [it is now know they breach many organs]. By 2004, I learned particular emfs also breach the tight junctions. By 2006, I learned tj permeability was genetic, leading to increased permeability in about 22 to 24% of the population. At that time, I had to wonder whether those of us with ES (and other diseases such as FM, CFS, MCS, MS, dysautonomia (ANSD), besides celiac disease, are all among those with this tj permeability genetic profile and I mentioned this at this forum around that time or possibly a bit later. For one thing--this would allow for why the cell phone industry was able to find NO side effects caused by cell phone use. [They cherry pick test subjects who are

normal (no cfs, no fms, no mcs, no....) instead of people with these diseases! They clearly state that they have done this on their studies.] Since that time, some researchers are making findings that are consistent with my thoughts that all these "new" diseases are infact linked. They are all thought to be "ion-channelopathy" diseases now. Celiac disease was known to be an ion-channelopathy since 2000.

Since that time, (finding other diseases ion-channel linked) doctors such as Goldsworthy have jumped on the bandwagon. There is continuing research every year that encourages me that this is not a dead-end. Marc mentions metal hoarding--esp mercury hoarding as a cause of ES. He is right, it is a cause! Mercury hoarding is also caused/ made harder to detox by tj permeability! There are research studies out there which show this, however, I sent dozens of these studies last year, and only a few people here were interested. And I didn't send the studies as I found them before that--with the subjects of what they showed, because before that *nobody* was interested. It was like Diane's latest, greatest adventure and nobody thought I was correct.

Unfortunately, since 2009, I no longer have the time to sift thru these studies and share them like I once could have. I am taking care of my elderly parents, an alzheimers father, and 3 houses. My time is now tied up in real life. Lucky I got enough info from the studies myself to at least help me! I have overcome cfs, fms, osteoporosis, (and more) and can well control my ANSD, diabetes, liver disease, chronic bronchial asthma, ES, and CD, so far. MCS has been the only one which has stayed very resistent. That and hand tremors still plague me. I assume that hand tremors are toxin related or from lack of a particular enzyme needed, which is GABA related. (GABA is something I cannot tolerate well, as it leaks into the bbb too readily, from tj permeability.)

The answers are out there to find if you search for them. But it takes work and time. We are all different, that is true; but we are also very much the same. The sources are there. Ask and you shall find. Do I know it all? Of course not; not even close to a millionth of 1 percent. But I know what I need to know as I continue to search and ask. I don't close my mind to any doors. If you do that, you will never find.

My quarter's worth,

Diane

--- On Tue, 5/31/11, emraware <[hidden email]> wrote:

From: emraware <[hidden email]>

Subject: [eSens] Various causes of ES symptoms

To: [hidden email]

Date: Tuesday, May 31, 2011, 8:48 PM

 

This might give you some suggestions such as increasing levels of antioxidants, getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php

--- In [hidden email], "Marc Martin" <marc@...> wrote:

>

> > I just listened to the talk by Dr. Andrew Goldsworthy about leaky cell membranes being the cause of ES symptoms. Can't say I understood all of it (brain-fog and all) but my question is this -- if that is the cause of all this misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this list. I think there are various causes of

ES, and you need to figure out which one applies to you. For example, I'm fairly certain that my ES is merely a side effect of mercury poisoning. While someone else may be suffering from a vitamin deficiency, someone else has a parasite problem, and someone else has leaky cell membranes. And many people here probably have a combination of several things going on.

>

> Marc

>

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Amen!  Great rant - and great summation of what our society has become.  

I sometimes forget that there are people who are probably e.s. - but don't know what the h*ll is going on (or are in some form of denial about it - after all, who would want to give up their elegant iPhones, or top-of-the-line Androids?).

Out of all of the chronic health conditions you listed, I have about 12 or 13 of them.  I am truly a product of modern society.

~Svetaswan

--- In [hidden email], Elizabeth thode <lizt777@...> wrote:

Thanks.
It's nice to know I'm in good company.  Yea, I probably started out with more things on the list then not!
Give up their precious big brother tracking system?
Here's another rant. 20 years ago, socieity was able to think on their feet! Now,instead of teaching kids to think for themselves, they get handed a cell phone. Gee, what happens if the battery goes bad? Or their in a bad tower area? They are so __ucked! They were/are only taught to press a button in case of emergency!
ON the victory side? WE are the lucky ones. WE have figured out WHO/ the enemy really IS. All those who are in denial...and I'd venture to say the list is LOOONG.....we are SO AHEAD OF THE GAME!!!
Lizzie
 


To: [hidden email]
From: [hidden email]
Date: Thu, 2 Jun 2011 18:04:33 +0000
Subject: [eSens] Re: leaky cell membranes


 





Amen! Great rant - and great summation of what our society has become.

I sometimes forget that there are people who are probably e.s. - but don't know what the h*ll is going on (or are in some form of denial about it - after all, who would want to give up their elegant iPhones, or top-of-the-line Androids?).

Out of all of the chronic health conditions you listed, I have about 12 or 13 of them. I am truly a product of modern society.

~Svetaswan

--- In [hidden email], Elizabeth thode <lizt777@...> wrote:


     

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