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> Hi, R,
>  
> Well, too soon to tell and highly unlikely.  ;)  I am probably one of the very few people at this forum who actually has been dxed with this by a doctor--tho by association, not by actual testing.  To my knowledge, there is no actual test for blood-brain barrier damage or tight-junction permeability of the bbb.  There may be calcium ion channel testing now,but my actual association is thru tight-junction permeability.  Untreated celiacs are known to have this (due to autopsy studies and animal and other studies.)  Also, it is highly suspected that about a third of treated celiacs have ongoing problems with either gut tjs +/or bbb tjs (this may now be known not just suspected, as there were tests to determine this going on at least a year ago).  I am considered to be one of those, dueto symptomology. 
>  
> The manganese (which I am experimenting with) is one substance I was able to find which can close channels which have been left "hanging open"--I found that from a medical research study performed on rabbits.  I have mentioned in a previous post today why I consider this risky and why othersshould not go there yet, tho.  I would not have gone there myself had itnot been the clear association I have with this medically and the number of signs of possible manganese deficiencies I have.  And still I am very careful to not over take the manganese. 
>  
> What I have found is, the manganese SOMETIMES helps for a period of about2 1/2 days.  When it does help, the es symptoms are all gone or extremely better for that amount of time.  However, it doesn't always help--sometimes I get nothing.  Also it doesn't last.  So I would always have touse the manganese, which might mean that it would become toxic.  Understand, the underlying problem is not a lack of manganese, the underlying problem is tjs or calcium ion channels leaking calcium and being left hanging open, due to too much calcium inside the cells as opposed to outside the cells.  Yes, manganese can then close them, but the original problem is not being addressed and within 2 1/2 days, the dysfunctional tjs +/or calcium ion channels again need closed (if this is what is indeed what is being addressed, and I think it probably is.)
>  
> Diane (or GHC to you, R  ;)  )
>
> --- On Tue, 5/5/09, rticleone <rticleone@...> wrote:
>
> From: rticleone <rticleone@...>
> Subject: [eSens] Re: Electrified anyone?
> To: [hidden email]
> Date: Tuesday, May 5, 2009, 4:34 PM
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> Diane - have you reached conclusions on how to address calcium ion channel defects and tight junction permeability? (Let alone diagnose them?)
>
> R.
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> --- In eSens@yahoogroups. com, Evie <evie15422@ ..> wrote:
> >
> > Hi again, Kooky,
> >  
> > I believe very much that calcium ion channel defects and tight junction permeability contribute to es and cfs/me.  (And celiac d. also has known association with tj permeability. )  I have been researching this online for the past year. 
> >  
> > Diane
> >
> > --- On Tue, 5/5/09, furstc0404 <furstc@> wrote:
> >
> > From: furstc0404 <furstc@>
> > Subject: [eSens] Re: Electrified anyone?
> > To: eSens@yahoogroups. com
> > Date: Tuesday, May 5, 2009, 4:40 AM
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> > Hi Marc:
> >
> > I forgot to ask, did you continue with raising your glut? or with vits and supps?
> >
> > Could it worsen these symptoms permanently?
> >
> > Surely, there must be a way of dealing with this?
> >
> > It is such a difficult decision as if to continue with vits and supps, and herbal remedy I am taking, because, I have noticed remarkable improvement. Unless of course, I am going through a good cycle...
> >
> > Thanks,
> >
> > Kooky
> >
> > PS. I was reading about calcium channels, action potential and various neuronal dysfunction. Any thoughts on this.
> >
> > --- In eSens@yahoogroups. com, "Marc Martin" <marc@> wrote:
> > >
> > > > Recently, I started developing, tingling and burning skin. On the face,
> > > > eyelids, arms and hands. Anyone else suffers from this?
> > >
> > > I have certainly had burning skin on my face.
> > >
> > > > The secondary issue, is that I started getting electric shocks from
> > > > water, clothes, cutlery, and other things I touch. This is happening
> > > > despite wearing thick rubber flip flops.
> > >
> > > "Despite"? I would think that thick rubber flip flops would actually
> > > contribute to shocks. Do you get shocks with bare feet or cotton
> > > socks?
> > >
> > > > Is it possible if taking vits and supps, and other alternative remedies
> > > > such as herbs, and powders, to exacerbate those symptoms too?
> > >
> > > Yes, my burning face gets worse with anything that raises glutathione
> > > levels, including Vitamin D. Also toxin mobilizers and chelators
> > > can make these symptoms worse (e.g. chlorella)
> > >
> > > Marc
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