Fisetin for Neuro-Protection

Fisetin for Neuro-Protection
_http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/)  
 
 
Fisetin is a unique polyphenol flavonoid that has  demonstrated a high
level of neuro protection along with memory  improvement.  A standardized
extract of fisetin is now  undergoing extensive scientific studies by the Salk
Institute for Biological  Studies to prove its value for general brain health.  
A patent has already  been issued, entitled “Methods of Using Flavonoids to
Enhance  Memory.”  It appears that fisetin is another useful nutrient tool  
to preserve cognitive well-being.
 
 
Fisetin is found in small amounts in many fruits and  vegetables including
mangoes and strawberries, although the standardized extract  comes from the
Japanese Wax Shrub/Tree (Rhus succedanea  – L).  There are thousands of
polyphenols in nature; some have  structures that are highly bioactive.  Some
examples include the  anthocyanins of blueberries, quercetin, grape seed
extract, resveratrol, and  green tea catechins.  In general such nutrients have
antioxidant,  anti-inflammatory, and gene-regulating attributes – in other
words they are  vital to human health.
 
 
Researchers came upon fisetin during a screening process  of many natural
substances.  They were looking for nutrients that could  prevent oxidative
stress from causing nerve cell death.   Oxidative stress to nerve cells is a
common problem, and always occurs in  situations of cognitive impairment and
decline.  Nerve protection is a top  priority for health, as nerves regulate
everything else; once they start to have  trouble, health declines.
 
 
We now know that the unique structure of each polyphenol  flavonoid means
that it may influence different gene pathways relating to nerve  function and
protection.  This is why it is good to have a mix of these  types of
nutrients in your supplements.  For example, the core  cellular antioxidant,
glutathione, is influenced by many flavonoids and  nutrients like grape seed
extract, R-alpha lipoic acid, tocotrienol E,  and NAC.  Fisetin operates in a
very specific pathway1 to boost  nerve cell glutathione levels and to reduce
one of the most damaging free  radicals, peroxynitrite.
 
 
Researchers have now documented a number of additional  ways in which
fisetin protects nerve cells during the aging process.  They  have shown that it
can protect nerve cells from damage during toxin-induced  stroke3 – while at
the same time maintaining the vital production of energy in  the brain (ATP
synthesis was preserved).  Excessive activation of the glial  cells in the
brain is associated with inflammatory nerve damage, excitotoxicity,  and
declining neurological health.  Fisetin has been shown to reduce excess  glial
cell activation4 upon exposure of nerve cells to a known neurotoxin.  
Fisetin has also been shown to reduce excessive formation of amyloid beta  
protein5 – a process that otherwise induces brain plaque associated with  
cognitive decline.
 
 
In addition to nerve protection, fisetin has been shown to  boost the
activity of gene pathways6 involved in memory improvement.  In  fact, data shows
that fisetin stimulates the growth of new nerve cells7  – a form of nerve
rejuvenation.
 
 
Collectively these studies demonstrate that  fisetin is a nutrient that
influences multiple pathways in a positive  way to protect the brain.  Since
the type of help fisetin offers  is related to factors that worsen with age,
the preliminary body of science  suggests that fisetin is a novel brain
anti-aging  nutrient.
 

Referenced  Studies:
 
1. _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline1)   _Fisetin  Boosts Cellular Glutathione_
(http://www.wellnessresources.com/studies/fisetin_boosts_cellular_glutathione/)  Brain
Res. Burdo J, Schubert D, Maher P.
 
 
2._^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline2)   _Fisetin  as a Nerve Anti-Aging Nutrient_
(http://www.wellnessresources.com/studies/fisetin_as_a_nerve_anti-aging_nutrient/)  
Genes Nutr. Pamela Maher
 
 
3. _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline3)   _Fisetin  Protects Against Stroke Damage_
(http://www.wellnessresources.com/studies/fisetin_protects_against_stroke_damage/)  
Brain Res. Maher P, Salgado KF, Zivin JA,  Lapchak PA.
 
 
4 _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline4)   _Fisetin  Prevents Excess Glial Cell Activation_
(http://www.wellnessresources.com/studies/fisetin_prevents_excess_glial_cell_activ
ation/)  Int Immunopharmacol. Zheng LT, Ock J,  Kwon BM, Suk K.
 
 
5. _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline5)   _Fisetin  Reduces Amyloid Beta Protein Formation_
(http://www.wellnessresources.com/studies/fisetin_reduces_amyloid_beta_protein_f
ormation/)  Neurosci Lett. Akaishi T, Morimoto T,  Shibao M, Watanabe S,
Sakai-Kato K, Utsunomiya-Tate N, Abe K.
 
 
6. _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline6)   _Fisetin  Boosts Memory_
(http://www.wellnessresources.com/studies/fisetin_boosts_memory/)  Proc Natl Acad Sci U S A. Maher P,
Akaishi T, Abe K.
 
 
7. _^_
(http://www.wellnessresources.com/health/articles/fisetin_for_neuro-protection/#inline7)   _Fisetin  Stimulates New Nerve Cell Growth_
(http://www.wellnessresources.com/studies/fisetin_stimulates_new_nerve_cell_growth/)  
J Neurochem. Sagara Y, Vanhnasy J, Maher P.

 

Related Entries:
 
_Fisetin:  Mood Boosting and Mind Protecting_
(http://www.wellnessresources.com/health/articles/fisetin_mood_boosting_and_mind_protecting/)


_Fisetin  Demonstrates Potent Anti-Cancer Properties_ (http://www.w
ellnessresources.com/health/articles/fisetin_demonstrates_potent_anti-cancer_properti
es/)
 

_ALC  and R-Alpha Lipoic Acid Reduce Brain Aging_
(http://www.wellnessresources.com/health/articles/alc_and_r_alpha_lipoic_acid_reduce_brain_aging/)


_Blueberries  for Your Brain_
(http://www.wellnessresources.com/health/articles/blueberries_for_your_brain/)
 
 
 


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